Single photon emission computed tomography experience with (S)‐5‐[123I]iodo‐3‐(2‐azetidinylmethoxy)pyridine in the living human brain of smokers and …
Abstract (S)‐5‐[123I] iodo‐3‐(2‐azetidinylmethoxy) pyridine (5‐[123I] IA), a novel potent
radioligand for high‐affinity α4β2* neuronal nicotinic acetylcholine receptors (nAChRs),
provides a means to evaluate the density and the distribution of nAChRs in the living human
brain. We sought in healthy adult smokers and nonsmokers to (1) evaluate the safety,
tolerability, and efficacy of 5‐[123I] IA in an open nonblind trial and (2) to estimate the
density and the distribution of α4β2* nAChRs in the brain. Single photon emission computed …
radioligand for high‐affinity α4β2* neuronal nicotinic acetylcholine receptors (nAChRs),
provides a means to evaluate the density and the distribution of nAChRs in the living human
brain. We sought in healthy adult smokers and nonsmokers to (1) evaluate the safety,
tolerability, and efficacy of 5‐[123I] IA in an open nonblind trial and (2) to estimate the
density and the distribution of α4β2* nAChRs in the brain. Single photon emission computed …
Single photon emission computed tomography experience with (S)-5-[(123) I] iodo-3-(2-azetidinylmethoxy) pyridine in the living human brain of smokers and …
Abstract (S)-5-[123 I] iodo-3-(2-azetidinylmethoxy) pyridine (5-[123 I] IA), a novel potent
radioligand for high-affinity α4β2* neuronal nicotinic acetylcholine receptors (nAChRs),
provides a means to evaluate the density and the distribution of nAChRs in the living human
brain. We sought in healthy adult smokers and nonsmokers to (1) evaluate the safety,
tolerability, and efficacy of 5-[123 I] IA in an open nonblind trial and (2) to estimate the
density and distribution of α 4 β 2* nAChRs in the brain. Single photon emission computed …
radioligand for high-affinity α4β2* neuronal nicotinic acetylcholine receptors (nAChRs),
provides a means to evaluate the density and the distribution of nAChRs in the living human
brain. We sought in healthy adult smokers and nonsmokers to (1) evaluate the safety,
tolerability, and efficacy of 5-[123 I] IA in an open nonblind trial and (2) to estimate the
density and distribution of α 4 β 2* nAChRs in the brain. Single photon emission computed …