Single Residue Mutation in Active Site of Serine Acetyltransferase Isoform 3 from Entamoeba histolytica Assists in Partial Regaining of Feedback Inhibition by …
The cysteine biosynthetic pathway is essential for survival of the protist pathogen
Entamoeba histolytica, and functions by producing cysteine for countering oxidative attack
during infection in human hosts. Serine acetyltransferase (SAT) and O-acetylserine
sulfhydrylase (OASS) are involved in cysteine biosynthesis and are present in three isoforms
each. While EhSAT1 and EhSAT2 are feedback inhibited by end product cysteine, EhSAT3
is nearly insensitive to such inhibition. The active site residues of EhSAT1 and of EhSAT3 …
Entamoeba histolytica, and functions by producing cysteine for countering oxidative attack
during infection in human hosts. Serine acetyltransferase (SAT) and O-acetylserine
sulfhydrylase (OASS) are involved in cysteine biosynthesis and are present in three isoforms
each. While EhSAT1 and EhSAT2 are feedback inhibited by end product cysteine, EhSAT3
is nearly insensitive to such inhibition. The active site residues of EhSAT1 and of EhSAT3 …
Single residue mutation in active site of serine acetyltransferase isoform 3 from Entamoeba histolytica assists in partial regaining of feedback inhibition by cysteine.
SK Sudhir Kumar, MM Mohit Mazumder… - 2013 - cabidigitallibrary.org
The cysteine biosynthetic pathway is essential for survival of the protist pathogen
Entamoeba histolytica, and functions by producing cysteine for countering oxidative attack
during infection in human hosts. Serine acetyltransferase (SAT) and O-acetylserine
sulfhydrylase (OASS) are involved in cysteine biosynthesis and are present in three isoforms
each. While EhSAT1 and EhSAT2 are feedback inhibited by end product cysteine, EhSAT3
is nearly insensitive to such inhibition. The active site residues of EhSAT1 and of EhSAT3 …
Entamoeba histolytica, and functions by producing cysteine for countering oxidative attack
during infection in human hosts. Serine acetyltransferase (SAT) and O-acetylserine
sulfhydrylase (OASS) are involved in cysteine biosynthesis and are present in three isoforms
each. While EhSAT1 and EhSAT2 are feedback inhibited by end product cysteine, EhSAT3
is nearly insensitive to such inhibition. The active site residues of EhSAT1 and of EhSAT3 …
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