Skin inflammation in RelB−/− mice leads to defective immunity and impaired clearance of vaccinia virus
EJ Freyschmidt, CB Mathias, DH MacArthur… - Journal of allergy and …, 2007 - Elsevier
BACKGROUND: Atopic dermatitis (AD) is an inflammatory skin disorder occurring in
genetically predisposed individuals with a systemic TH2 bias. Atopic dermatitis patients
exposed to the smallpox vaccine, vaccinia virus (VV), occasionally develop eczema
vaccinatum (EV), an overwhelming and potentially lethal systemic infection with VV.
OBJECTIVE: To establish a murine model of EV and examine the effects of skin
inflammation on VV immunity. METHODS: The skin of RelB−/− mice, like that of chronic AD …
genetically predisposed individuals with a systemic TH2 bias. Atopic dermatitis patients
exposed to the smallpox vaccine, vaccinia virus (VV), occasionally develop eczema
vaccinatum (EV), an overwhelming and potentially lethal systemic infection with VV.
OBJECTIVE: To establish a murine model of EV and examine the effects of skin
inflammation on VV immunity. METHODS: The skin of RelB−/− mice, like that of chronic AD …
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