… regulates Snail activation and subsequent cell migration. Our findings identify snail as a HIF
target gene and provide novel insights into the regulation of snail and hypoxia-induced EMT…

… Our data suggested that HIF-1α might be an upregulator of the SNAIL gene and HIF-1α-SNAIL-E-cad …
Such results confirmed that the SNAIL gene might be a target gene of HIF-1α. …

… HIF-1α-binding to the second site of HRE of the Snail gene promoter. Our findings confirmed
that Snail is a direct transcriptional target of HIF… of both HIF-1α and Snail was upregulated in …

… The effect of hypoxia on any given cell is mediated by hypoxia-inducible factor (HIF) … response
elements within promoter regions of target genes and induce transcriptional activity. Once …

… for potential targets of miR-128 using Target-Scan database. RPS6KB1 appeared as one
of the hypothetical target genes of miR-128 (Fig. 5a). RPS6KB1 is implicated in HIF-1α …

… The former is the most important factor induced by hypoxia because HIF-1α controls the
expression of target genes containing hypoxic response elements (HREs) in their promoters. …

… the target gene expression to that of … Snail expression was enhanced in HIF-1α-expressing
PC3 cells confirming our hypothesis of TNF-α and HIF-α synergistic activity in inducing Snail …

… Concordantly, tumor cells devoid of VHL have enhanced expression of HIF target genes,
such as VEGF (vascular endothelial growth factor; angiogenesis), GLUT-1 (glucose transporter …

… have common transcriptional targets, including genes involved in … Activation of Snail was
accompanied by increased N-… of HIF-1α or HIF-2α to the promoter region, suggesting that HIF-…

… , Snail interacts with several corepressors and epigenetic remodeling complexes to repress
specific target genes, such as the E-cadherin gene (… hypoxia-inducible factor 1 (HIF-1 ) to the …