Early life stress compromises brain development and can contribute to the development of
mental illnesses. A common animal model used to study different facets of psychiatric
disorders is social isolation from early life on. In rats, this isolation can induce long-lasting
alterations in molecular expression and in behavior. Since social isolation models severe
psychiatric symptoms, it is to be expected that it affects the overall wellbeing of the animals.
As also promoted by the 3Rs principle, though, it is pivotal to decrease the burden of …

Correction: Social isolation in rats: Effects on animal welfare and molecular markers for
neuroplasticity … Correction: Social isolation in rats: Effects on animal welfare and
molecular markers for neuroplasticity … (2020) Social isolation in rats: Effects on animal
welfare and molecular markers for neuroplasticity. PLOS ONE 15(10): e0240439. https://doi.org/
10.1371/journal.pone.0240439 …