Specificity of vascular endothelial growth factor treatment for radiation necrosis
CJ Perez-Torres, L Yuan, RE Schmidt, KM Rich… - Radiotherapy and …, 2015 - Elsevier
Recently, radiation induced necrosis in the brain has been treated using bevacizumab, an
anti-VEGF antibody. We validated the VEGF specificity by comparing the therapeutic efficacy
of anti-VEGF with non-specific isotype control antibody. Additionally, we found that VEGF
over-expression and RN developed simultaneously, which precludes preventative anti-
VEGF treatment.
anti-VEGF antibody. We validated the VEGF specificity by comparing the therapeutic efficacy
of anti-VEGF with non-specific isotype control antibody. Additionally, we found that VEGF
over-expression and RN developed simultaneously, which precludes preventative anti-
VEGF treatment.
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