The ability of luteolin, kaempferol and apigenin to bind to calf thymus (ct)-DNA, mode of
action and stability of flavonoids in buffer were investigated. Spectrophotometric analysis
revealed a rapid degradation of apigenin in an aqueous medium, while kaempferol and
luteolin were stable for 24h upon dissolution in water. Spectrophotometric study of the
interactions of kaempferol and luteolin with calf thymus DNA suggests classic intercalation
as their dominant binding mode to DNA. Cytotoxicity/genotoxicity and cytoprotective …