[PDF][PDF] Spermine and Spermidine as Gating Molecules for Inward Rectifier K'Channels
R Huybrechts, A DeLoof, LH Hirning… - J. Am. Chem …, 1983 - researchgate.net
Inward rectifier K'channels pass prominent inward currents, while outward currents are
largely blocked. The inward rectification is due to block by intracellular Mg2+ and a Mg2+-
independent process described as intrinsic gating. The rapid loss of gating upon patch
excision suggests that cytoplasmic factors participate in gating." Intrinsic" gating can be
restored in excised patches by nanomolar concentrations of two naturally occurring
polyamines, spermine and spermidine. Spermine and spermidine may function as …
largely blocked. The inward rectification is due to block by intracellular Mg2+ and a Mg2+-
independent process described as intrinsic gating. The rapid loss of gating upon patch
excision suggests that cytoplasmic factors participate in gating." Intrinsic" gating can be
restored in excised patches by nanomolar concentrations of two naturally occurring
polyamines, spermine and spermidine. Spermine and spermidine may function as …
Spermine and Spermidine as Gating Molecules for Inward Rectifier K+ Channels
E Ficker, M Taglialatela, BA Wible, CM Henley… - Science, 1994 - science.org
Inward rectifier K+ channels pass prominent inward currents, while outward currents are
largely blocked. The inward rectification is due to block by intracellular Mg2+ and a Mg2+-
independent process described as intrinsic gating. The rapid loss of gating upon patch
excision suggests that cytoplasmic factors participate in gating." Intrinsic" gating can be
restored in excised patches by nanomolar concentrations of two naturally occurring
polyamines, spermine and spermidine. Spermine and spermidine may function as …
largely blocked. The inward rectification is due to block by intracellular Mg2+ and a Mg2+-
independent process described as intrinsic gating. The rapid loss of gating upon patch
excision suggests that cytoplasmic factors participate in gating." Intrinsic" gating can be
restored in excised patches by nanomolar concentrations of two naturally occurring
polyamines, spermine and spermidine. Spermine and spermidine may function as …
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