Sphingolipid Biosynthetic Pathway Genes FEN1 and SUR4 Modulate Amphotericin B Resistance
Deletants of the sphingolipid biosynthetic pathway genes FEN1 and SUR4 of
Saccharomyces cerevisiae, as well as deletants of their orthologs in Candida albicans, were
found to be 2-to 5-fold-more sensitive to amphotericin B (AmB) than parent strains. The
inhibition of sphingolipid biosynthesis in parent strains by myriocin sensitized them to AmB,
which can be reversed by providing phytosphingosine, an intermediate in the sphingolipid
pathway. These results indicate that sphingolipids modulate AmB resistance, with …
Saccharomyces cerevisiae, as well as deletants of their orthologs in Candida albicans, were
found to be 2-to 5-fold-more sensitive to amphotericin B (AmB) than parent strains. The
inhibition of sphingolipid biosynthesis in parent strains by myriocin sensitized them to AmB,
which can be reversed by providing phytosphingosine, an intermediate in the sphingolipid
pathway. These results indicate that sphingolipids modulate AmB resistance, with …
Sphingolipid biosynthetic pathway genes FEN1 and SUR4 modulate amphotericin B resistance.
SS Sushma Sharma, M Alfatah, VK Bari… - 2014 - cabidigitallibrary.org
Deletants of the sphingolipid biosynthetic pathway genes FEN1 and SUR4 of
Saccharomyces cerevisiae, as well as deletants of their orthologs in Candida albicans, were
found to be 2-to 5-fold-more sensitive to amphotericin B (AmB) than parent strains. The
inhibition of sphingolipid biosynthesis in parent strains by myriocin sensitized them to AmB,
which can be reversed by providing phytosphingosine, an intermediate in the sphingolipid
pathway. These results indicate that sphingolipids modulate AmB resistance, with …
Saccharomyces cerevisiae, as well as deletants of their orthologs in Candida albicans, were
found to be 2-to 5-fold-more sensitive to amphotericin B (AmB) than parent strains. The
inhibition of sphingolipid biosynthesis in parent strains by myriocin sensitized them to AmB,
which can be reversed by providing phytosphingosine, an intermediate in the sphingolipid
pathway. These results indicate that sphingolipids modulate AmB resistance, with …
以上显示的是最相近的搜索结果。 查看全部搜索结果