Dense dissociated hippocampal cultures are known to generate spontaneous bursting
electrical activity which can be recorded by multielectrode arrays. We have analyzed spatio-
temporal profiles of the distribution of spikes in the bursts recorded after 2 weeks in vitro. We
have found a statistically significant similarity between the spiking patterns in sequential
bursting events, we refer to these spiking patterns as spiking signatures. Such spiking
signatures may appear in different parts of the bursts, including the activation patterns–the …