Statistical mechanics of a correlated energy landscape model for protein folding funnels
In heteropolymers, energetic correlations exist due to polymeric constraints and the locality
of interactions. Pair correlations in conjunction with the a priori specification of the existence
of a particularly low energy state provide a method of introducing the aspect of minimal
frustration to the energy landscapes of random heteropolymers. The resulting funneled
landscape exhibits both a phase transition from a molten globule to a folded state, and the
heteropolymeric glass transition in the globular state. We model the folding transition in the …
of interactions. Pair correlations in conjunction with the a priori specification of the existence
of a particularly low energy state provide a method of introducing the aspect of minimal
frustration to the energy landscapes of random heteropolymers. The resulting funneled
landscape exhibits both a phase transition from a molten globule to a folded state, and the
heteropolymeric glass transition in the globular state. We model the folding transition in the …
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