Objective: Pituitary adenomas are very common neoplasms and represent between 10 and
20% of all primary brain tumors. Historically, the treatment armamentarium for pituitary
adenomas included medical management, microsurgery, and fractionated radiotherapy.
More recently, radiosurgery has emerged as a viable treatment option. The goal of this
research is to define accurately the efficacy, safety, and role of radiosurgery for treatment of
pituitary adenomas. Methods: Medical literature databases from 1965 to 2003 were …

Pituitary adenomas are not just one of the most common intracranial tumors but also one of
the most difficult to cure. Neurosurgeons have adapted their tools to include precise ionizing
radiation in the form of the gamma knife to treat pituitary adenomas. The use of the gamma
knife in the management of pituitary adenomas following microsurgery or in selected cases
as a primary treatment is safe. The combined application of transsphenoidal surgery and
Gamma Knife surgery is beneficial in many difficult cases. However in some patients …