Neuroactive steroids are secretory products of peripheral endocrine glands that modulate a
variety of brain functions. A close relationship between neuroactive steroid structure and
function becomes most evident under pathological circumstances. On one side,
overproduction of glucocorticoid and mineralocorticoid neuroactive steroids may be
detrimental to the hippocampus, which is enriched in glucocorticoid receptors (GR) and
mineralocorticoid receptors (MR). Thus, a dysfunction of the adrenocortical system in aging …