Stimulation of RNA Polymerase II ubiquitination and degradation by yeast mRNA 3′-end processing factors is a conserved DNA damage response in eukaryotes
JN Kuehner, JW Kaufman, C Moore - DNA repair, 2017 - Elsevier
The quality and retrieval of genetic information is imperative to the survival and reproduction
of all living cells. Ultraviolet (UV) light induces lesions that obstruct DNA access during
transcription, replication, and repair. Failure to remove UV-induced lesions can abrogate
gene expression and cell division, resulting in permanent DNA mutations. To defend against
UV damage, cells utilize transcription-coupled nucleotide excision repair (TC-NER) to
quickly target lesions within active genes. In cases of long-term genotoxic stress, a slower …
of all living cells. Ultraviolet (UV) light induces lesions that obstruct DNA access during
transcription, replication, and repair. Failure to remove UV-induced lesions can abrogate
gene expression and cell division, resulting in permanent DNA mutations. To defend against
UV damage, cells utilize transcription-coupled nucleotide excision repair (TC-NER) to
quickly target lesions within active genes. In cases of long-term genotoxic stress, a slower …
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