Stimulation of central β2-adrenoceptors suppresses NFκB activity in rat brain: a role for IκB

KJ Ryan, É Griffin, JD Yssel, KM Ryan… - Neurochemistry …, 2013 - Elsevier
In this study we examined the impact of systemic treatment with the long-acting brain
penetrant β 2-adrenoceptor agonist clenbuterol on NFκB activity and IκB expression in rat
brain. Clenbuterol decreased NFκB activity (p65 DNA binding) in nuclear extracts prepared
from rat cortex and hippocampus for up to 8 h following a single treatment. This was
accompanied by increased expression of IκBα mRNA and protein. The temporal increase in
IκB protein expression paralleled the suppression of NFκB activity, suggesting that IκBα …
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