The paper essentially deals with the stratospheric distribution of methane (CH₄) over the Indian region, based on satellite-borne Michelson Interferometer for Passive Atmospheric Sounding (MIPAS) data as observed during 2003–2012 period. The inter-dependence of CH₄ and other trace gases such as Water vapour (H₂O), Ozone (O₃), and Nitric oxide (NO), variation of the equivalent water and long-term trends in CH₄ and H₂O is also presented. The CH₄ mixing ratio exhibits significant latitudinal and altitudinal dependence. The mixing ration of CH₄ varies in the range that goes from [1.8, 2.1] Part per Million by Volume (ppmv) to [1.2, 1.4] ppmv in the upper troposphere to the lower stratosphere. An out of phase relationship is observed between CH₄ and H₂O in the stratosphere in all the three-latitude regions (0° to 10° N, 10° to 25° N, and 25° to 40° N) addressed in this analysis. It is estimated that about 2.7 molecules of H₂O are produced as a result of oxidation of CH₄ and the excess in H₂O molecules is attributed to other production photochemical process, most important one being the oxidation of H₂. The dependence of CH₄ to O₃ and NO is altitude dependent, exhibiting an exponential decrease in the lower stratosphere and linear relation in the upper stratosphere. The analysis of the equivalent water in the mid-stratosphere shows an irregular variation in the altitude of 23–35 km and a gradual increase as the height increases. The overall change in equivalent water in the stratospheric region is [1, 2] ppmv. No consistent trend is observed in stratospheric CH₄. On the other hand, H₂O depicts an overall increase.