Plants are constantly subjected to biotic and abiotic stress factors, from their planting time up to the harvesting, transport, storage and consumption of plant products. These stresses exert deleterious harmful effects on crop health as well as cause huge losses to their production worldwide. To combat these stress factors, researchers all around the globe are involved in procuring management practices ranging from traditional genetics and breeding techniques to present day available novel biotechnological tools. Use of microorganisms is one such method by which both abiotic and biotic stress can be tackled in an economical, ecofriendly and successful manner. Plant growth-promoting rhizobacteria (PGPR) are the bacteria living in rhizosphere region and promoting plant growth and suppressing stress components as well. Different microorganisms acquire different mechanisms to fight with these plant stresses. In this chapter, an effort has been made to impart the knowledge about the abiotic and biotic stress factors, their management in an efficient and novel way.