Stromal Gli signaling regulates the activity and differentiation of prostate stem and progenitor cells
Interactions between cells in the stroma and epithelium facilitate prostate stem cell activity
and tissue regeneration capacity. Numerous molecular signal transduction pathways,
including the induction of sonic hedgehog (Shh) to activate the Gli transcription factors, are
known to mediate the cross-talk of these two cellular compartments. However, the details of
how these signaling pathways regulate prostate stem and progenitor cell activity remain
elusive. Here we demonstrate that, although cell-autonomous epithelial Shh-Gli signaling is …
and tissue regeneration capacity. Numerous molecular signal transduction pathways,
including the induction of sonic hedgehog (Shh) to activate the Gli transcription factors, are
known to mediate the cross-talk of these two cellular compartments. However, the details of
how these signaling pathways regulate prostate stem and progenitor cell activity remain
elusive. Here we demonstrate that, although cell-autonomous epithelial Shh-Gli signaling is …
[PDF][PDF] Stromal Gli signaling regulates the activity and differentiation of prostate stem and progenitor cells Qianjin Li1, Omar A. Alsaidan1 Sumit Rai2, Meng Wu1 …
Interactions between cells in the stroma and epithelium facilitate prostate stem cell activity
and tissue regeneration capacity. Numerous molecular signal transduction pathways,
including the induction of sonic hedgehog (Shh) to activate the Gli transcription factors, are
known to mediate the crosstalk of these two cellular compartments. However, the details of
how these signaling pathways regulate prostate stem and progenitor cell activity remain
elusive. Here we demonstrate that while cell autonomous epithelial Shh-Gli signaling is …
and tissue regeneration capacity. Numerous molecular signal transduction pathways,
including the induction of sonic hedgehog (Shh) to activate the Gli transcription factors, are
known to mediate the crosstalk of these two cellular compartments. However, the details of
how these signaling pathways regulate prostate stem and progenitor cell activity remain
elusive. Here we demonstrate that while cell autonomous epithelial Shh-Gli signaling is …
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