Rv3488 of Mycobacterium tuberculosis H37Rv has been assigned to the phenolic acid
decarboxylase repressor (PadR) family of transcriptional regulators that play key roles in
multidrug resistance and virulence of prokaryotes. The binding of cadmium, zinc, and
several other metals to Rv3488 was discovered and characterized by isothermal titration
calorimetery to be an exothermic process. Crystal structures of apo-Rv3488 and Rv3488 in
complex with cadmium or zinc ions were determined by X-ray crystallography. The structure …

Rv3488 of Mycobacterium tuberculosis H37Rv has been assigned to the phenolic acid
decarboxylase repressor (PadR) family of transcriptional regulators that play key roles in
multidrug resistance and virulence of prokaryotes. The binding of cadmium, zinc, and
several other metals to Rv3488 was discovered and characterized by isothermal titration
calorimetery to be an exothermic process. Crystal structures of apo-Rv3488 and Rv3488 in
complex with cadmium or zinc ions were determined by X-ray crystallography. The structure …