Structural-dynamics and binding analysis of RBD from SARS-CoV-2 variants of concern (VOCs) and GRP78 receptor revealed basis for higher infectivity
Glucose-regulated protein 78 (GRP78) might be a receptor for SARS-CoV-2 to bind and
enter the host cell. Recently reported mutations in the spike glycoprotein unique to the
receptor-binding domain (RBD) of different variants might increase the binding and
pathogenesis. However, it is still not known how these mutations affect the binding of RBD to
GRP78. The current study provides a structural basis for the binding of GRP78 to the
different variants, ie, B. 1.1. 7, B. 1.351, B. 1.617, and P. 1 (spike RBD), of SARS-CoV-2 …
enter the host cell. Recently reported mutations in the spike glycoprotein unique to the
receptor-binding domain (RBD) of different variants might increase the binding and
pathogenesis. However, it is still not known how these mutations affect the binding of RBD to
GRP78. The current study provides a structural basis for the binding of GRP78 to the
different variants, ie, B. 1.1. 7, B. 1.351, B. 1.617, and P. 1 (spike RBD), of SARS-CoV-2 …
以上显示的是最相近的搜索结果。 查看全部搜索结果