Structure determination of T cell protein-tyrosine phosphatase
LF Iversen, KB Møller, AK Pedersen, GH Peters… - Journal of Biological …, 2002 - ASBMB
Protein-tyrosine phosphatase 1B (PTP1B) has recently received much attention as a
potential drug target in type 2 diabetes. This has in particular been spurred by the finding
that PTP1B knockout mice show increased insulin sensitivity and resistance to diet-induced
obesity. Surprisingly, the highly homologous T cell protein-tyrosine phosphatase (TC-PTP)
has received much less attention, and no x-ray structure has been provided. We have
previously co-crystallized PTP1B with a number of low molecular weight inhibitors that …
potential drug target in type 2 diabetes. This has in particular been spurred by the finding
that PTP1B knockout mice show increased insulin sensitivity and resistance to diet-induced
obesity. Surprisingly, the highly homologous T cell protein-tyrosine phosphatase (TC-PTP)
has received much less attention, and no x-ray structure has been provided. We have
previously co-crystallized PTP1B with a number of low molecular weight inhibitors that …
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