Structure of the subunit binding domain and dynamics of the di-domain region from the core of human branched chain α-ketoacid dehydrogenase complex

CF Chang, HT Chou, YJ Lin, SJ Lee, JL Chuang… - Journal of Biological …, 2006 - ASBMB
The homo-24-meric dihydrolipoyl transacylase (E2) scaffold of the human branched-chain α-
ketoacid dehydrogenase complex (BCKDC) contains the lipoyl-bearing domain (hbLBD),
the subunit-binding domain (hbSBD) and the inner core domain that are linked to carry out
E2 functions in substrate channeling and recognition. In this study, we employed NMR
techniques to determine the structure of hbSBD and dynamics of several truncated
constructs from the E2 component of the human BCKDC, including hbLBD (residues 1-84) …
以上显示的是最相近的搜索结果。 查看全部搜索结果