Study on recognition of novel RACK1 protein inhibitors for small cell lung cancer outlined by pharmacophore based virtual screening and molecular docking
K Langeswaran, N Suganya, P Sangavi - Biocatalysis and Agricultural …, 2019 - Elsevier
An effort has been initiated to design pharmacophore-based 3D models pertaining to human
RACK1 protein,(receptor of activated kinase-1) inhibitors were generated with accurate
predictability. Such lead compounds were subsequently validated by screening measures to
determine its biological activities and its adaptable stability in the systems. The benchmark
for virtual screening was also treated to examine the selective RACK1 inhibitors. As a result
of virtual screening experiment and in vitro evaluation of lead candidate compounds …
RACK1 protein,(receptor of activated kinase-1) inhibitors were generated with accurate
predictability. Such lead compounds were subsequently validated by screening measures to
determine its biological activities and its adaptable stability in the systems. The benchmark
for virtual screening was also treated to examine the selective RACK1 inhibitors. As a result
of virtual screening experiment and in vitro evaluation of lead candidate compounds …
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