Methodology of rational seasonal scenario of inter-farm combine harvester threshers use that is based of the design and management of technological processes of harvesting of early grain crops is revealed. The proposed methodology involves a step-by-step study of the combined influence of natural-production and agrometeorological factors on the efficiency of the technological processes of harvesting early grains and the monetary evaluation of these indicators. This gives reason to justify on cost criteria (profit earned by reducing the yield loss of the crop), rational seasonal scenario of inter-farm combine harvester threshers use by business entities, united geographically or administratively. The automated system for designing and controlling the processes of harvesting early grain crops, which was created to implement this technique, also described. Using this automated system allows: for each business entity to predict fields for which there is a risk of loss of cultivated yield due to the untimely harvest of it by the available fleet of combines; to define combine harvesters which must additionally involve to the harvesting on such fields; to predict the duration of the involvement of these harvesters and select business entities from which it is expedient to involve combine harvesters. The developed automated system makes it possible to increase the efficiency of the use of combine harvesters of economic entities and to reduce the losses of the cultivated harvest of early grain crops.