Substitution mutational signatures in whole-genome–sequenced cancers in the UK population
A Degasperi, X Zou, T Dias Amarante… - Science, 2022 - science.org
Whole-genome sequencing (WGS) permits comprehensive cancer genome analyses,
revealing mutational signatures, imprints of DNA damage, and repair processes that have
arisen in each patient's cancer. We performed mutational signature analyses on 12,222
whole-genome–sequenced tumor-normal matched pairs from patients recruited via the UK
National Health Service (NHS). We contrasted our results with two independent cancer WGS
datasets—from the International Cancer Genome Consortium (ICGC) and the Hartwig …
revealing mutational signatures, imprints of DNA damage, and repair processes that have
arisen in each patient's cancer. We performed mutational signature analyses on 12,222
whole-genome–sequenced tumor-normal matched pairs from patients recruited via the UK
National Health Service (NHS). We contrasted our results with two independent cancer WGS
datasets—from the International Cancer Genome Consortium (ICGC) and the Hartwig …
以上显示的是最相近的搜索结果。 查看全部搜索结果