Sunitinib in combination with clarithromycin or azithromycin–is there a risk of interaction or not?
E Szałek, A Karbownik, W Połom, M Matuszewski… - Pharmacological …, 2012 - Elsevier
Background Macrolides are the most widely prescribed antibiotics. Clarithromycin is a well-
known inhibitor of cytochrome P450 CYP3A4 and causes numerous drug interactions that
are not found for azithromycin. CYP3A4 is involved in the metabolism of the new oral
multikinase inhibitor sunitinib and its active N-desethyl metabolite (SU012662). This study
investigated the effects of oral single dose of clarithromycin or azithromycin on the
pharmacokinetics of sunitinib. Methods Rabbits were subjected to one of three study drug …
known inhibitor of cytochrome P450 CYP3A4 and causes numerous drug interactions that
are not found for azithromycin. CYP3A4 is involved in the metabolism of the new oral
multikinase inhibitor sunitinib and its active N-desethyl metabolite (SU012662). This study
investigated the effects of oral single dose of clarithromycin or azithromycin on the
pharmacokinetics of sunitinib. Methods Rabbits were subjected to one of three study drug …
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