Superoxide anion mediated mitochondrial dysfunction leads to hepatocyte apoptosis preferentially in the periportal region during copper toxicity in rats
DN Roy, S Mandal, G Sen, T Biswas - Chemico-Biological Interactions, 2009 - Elsevier
Chronic exposure to copper induces hepatocellular apoptosis with greater injury in the
periportal region compared to the perivenous region. Here we have identified the factors
responsible for the development of regional damage in the liver under in vivo conditions.
Enhanced production of reactive oxygen species (ROS) with predominance of superoxide
radical (O2−) indicates the contribution of redox imbalance in the process. This may be
linked with copper catalyzed oxidation of GSH to GSSG resulting in the generation of O2 …
periportal region compared to the perivenous region. Here we have identified the factors
responsible for the development of regional damage in the liver under in vivo conditions.
Enhanced production of reactive oxygen species (ROS) with predominance of superoxide
radical (O2−) indicates the contribution of redox imbalance in the process. This may be
linked with copper catalyzed oxidation of GSH to GSSG resulting in the generation of O2 …
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