Purpose.: To evaluate the change in thickness of the anterior, stromal, and posterior corneal
laminae in response to hypoxia-induced corneal swelling, by means of ultrahigh-resolution
optical coherence tomography (UHR-OCT). Methods.: A UHR-OCT system, operating in the
1060-nm range, was used to acquire in vivo cross-sectional images of human cornea with a
3.2× 10-μm (axial× lateral) resolution in corneal tissue. Corneal edema was induced by
inserting a thick, positive-powered, soft contact lens, over which the eye was closed and …

Purpose:: To evaluate the change in thickness of the anterior, stromal and posterior laminae
of the cornea in response to hypoxia induced corneal swelling using an ultra-high resolution
optical coherence tomographer (UHR-OCT). Methods:: The custom, high-speed UHR-OCT
system 1, operating in the 1060nm range, was used to obtain two dimensional images of the
cornea. The device acquires 47,000 A-scans per second and has a resolution in corneal
tissue of 3.2 µm (axial) and 10µm (lateral). Images were obtained from the right eye of five …