Synergistic effects of ischemia and β-amyloid burden on cognitive decline in patients with subcortical vascular mild cognitive impairment
Importance Cerebrovascular disease (CVD) and Alzheimer disease are significant causes of
cognitive impairment in the elderly. However, few studies have evaluated the relationship
between CVD and β-amyloid burden in living humans or their synergistic effects on
cognition. Thus, there is a need for better understanding of mild cognitive impairment (MCI)
before clinical deterioration begins. Objective To determine the synergistic effects of β-
amyloid burden and CVD on cognition in patients with subcortical vascular MCI (svMCI) …
cognitive impairment in the elderly. However, few studies have evaluated the relationship
between CVD and β-amyloid burden in living humans or their synergistic effects on
cognition. Thus, there is a need for better understanding of mild cognitive impairment (MCI)
before clinical deterioration begins. Objective To determine the synergistic effects of β-
amyloid burden and CVD on cognition in patients with subcortical vascular MCI (svMCI) …
Synergistic Effects of Ischemia and β-Amyloid Burden on Cognitive Decline in PatientsWith Subcortical Vascular Mild Cognitive Impairment
IMPORTANCE: Cerebrovascular disease (CVD) and Alzheimer disease are significant
causes of cognitive impairment in the elderly. However, few studies have evaluated the
relationship between CVD and β-amyloid burden in living humans or their synergistic effects
on cognition. Thus, there is a need for better understanding of mild cognitive impairment
(MCI) before clinical deterioration begins. OBJECTIVE: To determine the synergistic effects
of β-amyloid burden and CVD on cognition in patients with subcortical vascular MCI (svMCI) …
causes of cognitive impairment in the elderly. However, few studies have evaluated the
relationship between CVD and β-amyloid burden in living humans or their synergistic effects
on cognition. Thus, there is a need for better understanding of mild cognitive impairment
(MCI) before clinical deterioration begins. OBJECTIVE: To determine the synergistic effects
of β-amyloid burden and CVD on cognition in patients with subcortical vascular MCI (svMCI) …
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