Amino acid derivative Schiff base was synthesized by reaction of leucine with salicyldehyde in basic medium. The Schiff base was used as a ligand which was reacted with Co, Mn, Cu and Cd metals in order to form the stable complexes. The synthesized ligand and metals complexes were characterized by using different spectroscopic tools i.e. FT-IR, Mass spectrometry and NMR. The percentages of different elements present in ligand molecule and complexes was confirmed by Elemental analyzer. All compounds including ligand and complexes were also engaged with different bacterial (Escheria coli, Staphylococcus aureus, Bacillus subbtilis) and fungal strains (Alternaria alternate, Aspergillus flavus and Aspergillus niger) in order to check the inhibitory action of titled compounds. The results showed that the metal complexes have greater antimicrobial activities than ligand.