Synthesis and characterization of PnVCL grafted agar with potential temperature-sensitive delivery of Doxorubicin

C Voycheva, M Slavkova, T Popova, D Tzankova… - Journal of Drug Delivery …, 2022 - Elsevier
Thermo-responsive copolymer, Agar agar-graft-poly (N-vinylcaproactam)(AA-g-PnVCL) was
prepared by grafting N-vinylcaprolactam units onto the Agar backbone. Graft copolymer was
synthesized by free-radical polymerization, using 2, 2′-Azobis (2, 4-dimethylvaleronitrile)(
AMVN) as an initiator in the nitrogen atmosphere. In order to evaluate the composition effect
different ratios between Agar agar, nVCL and AMVN were used. The formation of AA-g-
PnVCL was confirmed by FT-IR, TGA, 1H NMR, and XRD techniques. Viscosity average …
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