Synthesis and in vitro evaluation of the anticancer activity of novel fluorinated thiazolo[4, 5‐d]pyrimidines
HTY Fahmy, SAF Rostom, MN Saudi… - … der Pharmazie: An …, 2003 - Wiley Online Library
Archiv der Pharmazie: An International Journal Pharmaceutical and …, 2003•Wiley Online Library
The synthesis of several thiazolo [4, 5‐d] pyrimidines containing a fluorophenyl moiety
substituted at different positions and through different bridges is described. Twenty new
compounds were prepared and evaluated for their anticancer activity using the USA‐NCI in‐
vitro screening program. Three compounds were found active and their anticancer activity
against 60 human tumor cell lines are described in detail.
substituted at different positions and through different bridges is described. Twenty new
compounds were prepared and evaluated for their anticancer activity using the USA‐NCI in‐
vitro screening program. Three compounds were found active and their anticancer activity
against 60 human tumor cell lines are described in detail.
Abstract
The synthesis of several thiazolo[4, 5‐d]pyrimidines containing a fluorophenyl moiety substituted at different positions and through different bridges is described. Twenty new compounds were prepared and evaluated for their anticancer activity using the USA‐NCI in‐vitro screening program. Three compounds were found active and their anticancer activity against 60 human tumor cell lines are described in detail.
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