Synthesis of Enamides via Rh/C-Catalyzed Direct Hydroacylation of Ketoximes
ZH Guan, K Huang, S Yu, X Zhang - Organic Letters, 2009 - ACS Publications
ZH Guan, K Huang, S Yu, X Zhang
Organic Letters, 2009•ACS PublicationsEnamides were efficiently prepared via a novel Rh/C-catalyzed direct hydroacylation of
ketoximes. Up to 88% isolated yield of enamides were obtained with this method.
Subsequent asymmetric hydrogenation of the enamides with Rh/DuanPhos complex gave
the corresponding chiral amine in excellent enantioselectivities (up to 99.7% ee).
ketoximes. Up to 88% isolated yield of enamides were obtained with this method.
Subsequent asymmetric hydrogenation of the enamides with Rh/DuanPhos complex gave
the corresponding chiral amine in excellent enantioselectivities (up to 99.7% ee).
Enamides were efficiently prepared via a novel Rh/C-catalyzed direct hydroacylation of ketoximes. Up to 88% isolated yield of enamides were obtained with this method. Subsequent asymmetric hydrogenation of the enamides with Rh/DuanPhos complex gave the corresponding chiral amine in excellent enantioselectivities (up to 99.7% ee).
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