Synthesis of axially chiral heterobiaryl alkynes via dynamic kinetic asymmetric alkynylation
Chemical Communications, 2016•pubs.rsc.org
The dynamic kinetic Pd0-catalyzed alkynylation of racemic heterobiaryl sulfonates was used
for the asymmetric synthesis of axially chiral heterobiaryl alkynes with a broad scope. The
use of Pd (OAc) 2/(S)-QUINAP as the precatalyst provides products in excellent yields and
enantioselectivities under mild conditions (DMSO, 40° C). Semireduction, 1, 3-dipolar
cycladdition or N-oxidation served to illustrate the synthetic potential of the methodology.
for the asymmetric synthesis of axially chiral heterobiaryl alkynes with a broad scope. The
use of Pd (OAc) 2/(S)-QUINAP as the precatalyst provides products in excellent yields and
enantioselectivities under mild conditions (DMSO, 40° C). Semireduction, 1, 3-dipolar
cycladdition or N-oxidation served to illustrate the synthetic potential of the methodology.
The dynamic kinetic Pd0-catalyzed alkynylation of racemic heterobiaryl sulfonates was used for the asymmetric synthesis of axially chiral heterobiaryl alkynes with a broad scope. The use of Pd(OAc)2/(S)-QUINAP as the precatalyst provides products in excellent yields and enantioselectivities under mild conditions (DMSO, 40 °C). Semireduction, 1,3-dipolar cycladdition or N-oxidation served to illustrate the synthetic potential of the methodology.
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