Synthesis of novel pyrimidine derivatives as bioisosters of Nifedipine and in vitro evaluation of their antihypertensive activity
3, 4-dihydropyrimidin-2 (1H) compounds have been attracted researchers to synthesize
them via Beginilli reaction and evaluate their antihypertensive activities as bioisosters of
nifedipine. The aim was to evaluate the antihypertensive activities of new synthetic
pyrimidine compounds compare with nifedipine. The new compounds were prepared from
one pot reaction of thiourea (1), ethyl acetoacetate (2) and/or p-nitrobenzaldehyde,
ptolualdehyde (3), respectively, in acid medium (HCl) yielding pyrimidine 4a-c which in turn …
them via Beginilli reaction and evaluate their antihypertensive activities as bioisosters of
nifedipine. The aim was to evaluate the antihypertensive activities of new synthetic
pyrimidine compounds compare with nifedipine. The new compounds were prepared from
one pot reaction of thiourea (1), ethyl acetoacetate (2) and/or p-nitrobenzaldehyde,
ptolualdehyde (3), respectively, in acid medium (HCl) yielding pyrimidine 4a-c which in turn …
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