PURPOSE: The discovery of effective biomarkers is a fundamental goal of molecular
medicine. Developing a systems–biology understanding of radiosensitivity can enhance our
ability of identifying radiation-specific biomarkers. METHODS AND MATERIALS:
Radiosensitivity, as represented by the survival fraction at 2 Gy was modeled in 48 human
cancer cell lines. We applied a linear regression algorithm that integrates gene expression
with biological variables, including ras status (mut/wt), tissue of origin and p53 status …