T263. Psilocybin improves cognitive control and downregulates parietal cortex in treatment-seeking smokers
Background Prior data suggests the 5-HT2A receptor agonist psilocybin (PSILO) improves
smoking cessation outcomes. Here, we examine cognitive and neurobiological mechanisms
underlying these encouraging results. The multi-source interference task (MSIT) is employed
as an assay of changes in cognitive control processes mediated by PSILO administration in
treatment-seeking smokers. Methods N= 9 treatment-seeking smokers performed the MSIT
while undergoing fMRI scanning during 2 sessions: prior to beginning cessation treatment …
smoking cessation outcomes. Here, we examine cognitive and neurobiological mechanisms
underlying these encouraging results. The multi-source interference task (MSIT) is employed
as an assay of changes in cognitive control processes mediated by PSILO administration in
treatment-seeking smokers. Methods N= 9 treatment-seeking smokers performed the MSIT
while undergoing fMRI scanning during 2 sessions: prior to beginning cessation treatment …