TINC—a method to dissect regulatory complexes at single-locus resolution—reveals an extensive protein complex at the nanog promoter
Cellular identity is ultimately dictated by the interaction of transcription factors with regulatory
elements (REs) to control gene expression. Advances in epigenome profiling techniques
have significantly increased our understanding of cell-specific utilization of REs. However, it
remains difficult to dissect the majority of factors that interact with these REs due to the lack
of appropriate techniques. Therefore, we developed TINC: TALE-mediated isolation of
nuclear chromatin. Using this new method, we interrogated the protein complex formed at …
elements (REs) to control gene expression. Advances in epigenome profiling techniques
have significantly increased our understanding of cell-specific utilization of REs. However, it
remains difficult to dissect the majority of factors that interact with these REs due to the lack
of appropriate techniques. Therefore, we developed TINC: TALE-mediated isolation of
nuclear chromatin. Using this new method, we interrogated the protein complex formed at …
[PDF][PDF] Article TINC—A Method to Dissect Regulatory Complexes at Single-Locus Resolution—Reveals an Extensive Protein Complex at the Nanog Promoter
YBY Sun, ML Holmes, P Tripathi, J Pflueger… - academia.edu
Cellular identity is ultimately dictated by the interaction of transcription factors with regulatory
elements (REs) to control gene expression. Advances in epigenome profiling techniques
have significantly increased our understanding of cell-specific utilization of REs. However, it
remains difficult to dissect the majority of factors that interact with these REs due to the lack
of appropriate techniques. Therefore, we developed TINC: TALE-mediated isolation of
nuclear chromatin. Using this new method, we interrogated the protein complex formed at …
elements (REs) to control gene expression. Advances in epigenome profiling techniques
have significantly increased our understanding of cell-specific utilization of REs. However, it
remains difficult to dissect the majority of factors that interact with these REs due to the lack
of appropriate techniques. Therefore, we developed TINC: TALE-mediated isolation of
nuclear chromatin. Using this new method, we interrogated the protein complex formed at …
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