TNFα-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve
VI Shubayev, M Angert, J Dolkas, WM Campana… - Molecular and Cellular …, 2006 - Elsevier
Matrix metalloproteinase-9 (MMP-9) is an extracellular protease that is induced hours after
injury to peripheral nerve. This study shows that MMP-9 gene deletion and neutralization
with MMP-9 antibody reduce macrophage content in injured wild-type nerves. In mice with
delayed Wallerian degeneration (WldS), MMP-9 and tumor necrosis factor alpha (TNFα)
decline in association with the reduced macrophage recruitment to injured nerve that
characterizes this strain of mice. We further determined that TNFα acts as an MMP-9 inducer …
injury to peripheral nerve. This study shows that MMP-9 gene deletion and neutralization
with MMP-9 antibody reduce macrophage content in injured wild-type nerves. In mice with
delayed Wallerian degeneration (WldS), MMP-9 and tumor necrosis factor alpha (TNFα)
decline in association with the reduced macrophage recruitment to injured nerve that
characterizes this strain of mice. We further determined that TNFα acts as an MMP-9 inducer …
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