TOP2A and EZH2 provide early detection of an aggressive prostate cancer subgroup
… aggressive genetically engineered mouse models (GEMM) of prostate cancer, we provide
the rational that a targeted combination therapy against TOP2A and EZH2 in a subset of …
the rational that a targeted combination therapy against TOP2A and EZH2 in a subset of …
TOP2A and EZH2 provide early detection of an aggressive prostate cancer subgroup
YH Bowden, KP Gray10, FY Feng11, DE Spratt12… - pcf.org
… aggressive disease and notable overlap of genes involved in mitotic regulation. Importantly,
TOP2A and EZH2 … assessment of TOP2A and EZH2 as biomarkers for early identification of …
TOP2A and EZH2 … assessment of TOP2A and EZH2 as biomarkers for early identification of …
Identification of core genes associated with prostate cancer progression and outcome via bioinformatics analysis in multiple databases
Y Wang, J Wang, K Yan, J Lin, Z Zheng, J Bi - PeerJ, 2020 - peerj.com
… 2 (EZH2) acts as the methyltransferase component of PRC2. Its enhancer regulation disorder
is widely found in many aggressive, advanced cancers (… , TK1, MKI67, TOP2A, CCNB1 and …
is widely found in many aggressive, advanced cancers (… , TK1, MKI67, TOP2A, CCNB1 and …
BAZ2A-RNA mediated association with TOP2A and KDM1A represses genes implicated in prostate cancer
M Roganowicz, D Bär, C Bersaglieri… - Life Science …, 2023 - life-science-alliance.org
… TOP2A and KDM1A repress genes critical to PCa and may prove to be useful to stratify prostate
cancer … underlying the more aggressive phenotype associated with TOP2A is not known. …
cancer … underlying the more aggressive phenotype associated with TOP2A is not known. …
Pre-existing castration-resistant prostate cancer–like cells in primary prostate cancer promote resistance to hormonal therapy
… Based on positive expression of SYP and EZH2 [22] and inactivated RB1 signaling, we …
cell markers, TOP2A has been used to define an aggressive PCa subgroup with increased …
cell markers, TOP2A has been used to define an aggressive PCa subgroup with increased …
[PDF][PDF] BAZ2A-RNA mediated association with TOP2A and KDM1A represses gene expression in prostate cancer
M Roganowicz, D Bär, R Santoro, R Santoro - bioRxiv, 2021 - scholar.archive.org
… TOP2A and KDM1A regulate gene expression in PCa and may prove to 28 be useful for the
stratification of prostate cancer … more 15 aggressive phenotype associated with TOP2A is not …
stratification of prostate cancer … more 15 aggressive phenotype associated with TOP2A is not …
Biomarkers of aggressiveness in genitourinary tumors with emphasis on kidney, bladder, and prostate cancer
A Cimadamore, S Gasparrini, M Santoni… - Expert review of …, 2018 - Taylor & Francis
… gained interest for the early detection of a subgroup of aggressive PCa. The concurrent
high expression of TOP2A and EZH2 mRNA and/or protein can identify a subgroup of high-risk …
high expression of TOP2A and EZH2 mRNA and/or protein can identify a subgroup of high-risk …
The 5-hydroxymethylcytosine landscape of prostate cancer
M Sjöström, SG Zhao, S Levy, M Zhang, Y Ning… - Cancer research, 2022 - AACR
… as a prognostic biomarker able to identify an aggressive subtype of prostate cancer using
the genes TOP2A and EZH2, previously only detectable by transcriptomic analysis of solid …
the genes TOP2A and EZH2, previously only detectable by transcriptomic analysis of solid …
Epigenetic regulation in prostate cancer progression
K Ruggero, S Farran-Matas, A Martinez-Tebar… - Current molecular …, 2018 - Springer
… Beyond a promising drug target, EZH2 and TOP2A have been … The subgroup of BET
proteins (bromodomain and extra-… and Ezh2 mediates suppression of prostate cancer lineage …
proteins (bromodomain and extra-… and Ezh2 mediates suppression of prostate cancer lineage …
Castration-resistant prostate cancer monitoring by cell-free circulating biomarkers
E Chrenková, H Študentová, K Holá… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
… of TOP2A and EZH2 has been identified for the aggressive disease… of the tumor
microenvironment with various subgroups of … Early detection of treatment failure followed by the …
microenvironment with various subgroups of … Early detection of treatment failure followed by the …