… 7,8 , it became clear that there was probably another TWEAK receptor. In 2001, Wiley et al.
… assumed that TWEAK activity on all cell types is mediated by this receptor. TWEAK activity …

… There is one receptor currently known to bind TWEAK with … to in the literature as either TWEAK
receptor (TweakR) or fibroblast … regarding TWEAK gene expression, receptor recognition, …

… Apoptosis induction by the TNFR1-related TRAIL death receptors is not or only poorly
enhanced by TWEAK treatment further indicating that Fn14 signalling affects an apoptosis-relevant …

… TWEAKinduced apoptosis critically depends on the autocrine/ paracrine action of induced
TNF. Moreover, as the response pattern of TWEAK in … of another TWEAK receptor distinct from …

… TWEAK is a member of the TNF ligand family that induces angiogenesis in vivo. We report
cloning of a receptor for TWEAK (… Five different assays demonstrate TWEAK-TweakR binding, …

… Indeed, therapeutics against several ligand and receptor superfamily members are either …
functions of its only known ligand, TWEAK (6). TWEAK has been shown to play various roles in …

… -anchored TWEAK and soluble TWEAK monomers assemble into trimers. TWEAK binding
to the Fn14 extracellular domain promotes Fn14 trimerization and binding of TNF receptor-…

… ) was suggested to be a receptor for TWEAK. We show that the Fn14/TWEAK receptor (TweakR)
was not responsible for the osteoclastic effect of TWEAK on RAW cells. Flow cytometry …

… Here we describe a new ligand in this family, designated TWEAK. The mouse … receptor
binding domain. The protein was efficiently secreted from cells indicating that, like TNF, TWEAK …

… These findings demonstrated that FGF-2, VEGF-A, and TWEAK might cooperate during
tumor angiogenesis via binding to their respective receptors on the endothelial cell surface (…