Genome-wide studies have defined cell type–specific patterns of DNA methylation that are
important for regulating gene expression in both normal development and disease.
However, determining the functional significance of specific methylation events remains
challenging, owing to the lack of methods for removing such modifications in a targeted
manner. Here we describe an approach for efficient targeted demethylation of specific CpGs
in human cells using fusions of engineered transcription activator–like effector (TALE) repeat …

Targeted DNA demethylation and activation of endogenous genes using programmable
TALE-TET1 fusion proteins … Genome-wide studies have defined cell type-specific patterns
of DNA methylation that are important for regulating gene expression in both normal
development and disease. However, determining the functional significance of specific
methylation events remain …