Targeting AMP‐activated kinase impacts hepatocellular cancer stem cells induced by long‐term treatment with sorafenib
A Bort, BG Sánchez, PA Mateos‐Gómez… - Molecular …, 2019 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. HCC
treatment is hindered by the frequent emergence of chemoresistance to the multikinase
inhibitor sorafenib, which has been related to the presence of cancer stem cells (CSC s) that
self‐renew and often escape therapy. The key metabolic sensor AMP‐activated kinase
(AMPK) has recently been recognized as a tumour growth regulator. In this study, we aimed
to elucidate the role of AMPK in the development of a stem cell phenotype in HCC cells. To …
treatment is hindered by the frequent emergence of chemoresistance to the multikinase
inhibitor sorafenib, which has been related to the presence of cancer stem cells (CSC s) that
self‐renew and often escape therapy. The key metabolic sensor AMP‐activated kinase
(AMPK) has recently been recognized as a tumour growth regulator. In this study, we aimed
to elucidate the role of AMPK in the development of a stem cell phenotype in HCC cells. To …
Targeting AMP-activated kinase impacts hepatocellular cancer stem cells induced by long-term treatment with sorafenib
AC Bort Bueno, B Sánchez Gómez, PA Mateos Gómez… - 2019 - ebuah.uah.es
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. HCC
treatment is hindered by the frequent emergence of chemoresistance to the multikinase
inhibitor sorafenib, which has been related to the presence of cancer stem cells (CSCs) that
self-renew and often escape therapy. The key metabolic sensor AMP-activated kinase
(AMPK) has recently been recognized as a tumour growth regulator. In this study, we aimed
to elucidate the role of AMPK in the development of a stem cell phenotype in HCC cells. To …
treatment is hindered by the frequent emergence of chemoresistance to the multikinase
inhibitor sorafenib, which has been related to the presence of cancer stem cells (CSCs) that
self-renew and often escape therapy. The key metabolic sensor AMP-activated kinase
(AMPK) has recently been recognized as a tumour growth regulator. In this study, we aimed
to elucidate the role of AMPK in the development of a stem cell phenotype in HCC cells. To …
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