[引用][C] Targeting Candida albicans filamentation for antifungal drug development. Virulence 8: 150–158

T Vila, JA Romo, CG Pierce, SF McHardy, SP Saville… - 2017

Targeting Candida albicans filamentation for antifungal drug development

T Vila, JA Romo, CG Pierce, SF McHardy, SP Saville… - Virulence, 2017 - Taylor & Francis
Candida albicans remains the main etiological agent of candidiasis, as this otherwise
normal commensal of humans is capable of causing active infection in immune-and
medically-compromised patients. The high morbidity and mortality rates associated with
candidiasis, coupled with the emergence of drug resistance demand the development of
novel therapeutic strategies. However, there is a paucity of selective targets that can be
exploited in the development of new antifungals. Contrary to conventional antibiotics that kill …
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