[引用][C] Targeting Candida albicans filamentation for antifungal drug development. Virulence 8: 150–158
T Vila, JA Romo, CG Pierce, SF McHardy, SP Saville… - 2017
Targeting Candida albicans filamentation for antifungal drug development
Candida albicans remains the main etiological agent of candidiasis, as this otherwise
normal commensal of humans is capable of causing active infection in immune-and
medically-compromised patients. The high morbidity and mortality rates associated with
candidiasis, coupled with the emergence of drug resistance demand the development of
novel therapeutic strategies. However, there is a paucity of selective targets that can be
exploited in the development of new antifungals. Contrary to conventional antibiotics that kill …
normal commensal of humans is capable of causing active infection in immune-and
medically-compromised patients. The high morbidity and mortality rates associated with
candidiasis, coupled with the emergence of drug resistance demand the development of
novel therapeutic strategies. However, there is a paucity of selective targets that can be
exploited in the development of new antifungals. Contrary to conventional antibiotics that kill …
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