Targeting galectin-3 to counteract spike-phase uncoupling of fast-spiking interneurons to gamma oscillations in Alzheimer's disease
Background Alzheimer's disease (AD) is a progressive multifaceted neurodegenerative
disorder for which no disease-modifying treatment exists. Neuroinflammation is central to the
pathology progression, with evidence suggesting that microglia-released galectin-3 (gal3)
plays a pivotal role by amplifying neuroinflammation in AD. However, the possible
involvement of gal3 in the disruption of neuronal network oscillations typical of AD remains
unknown. Methods Here, we investigated the functional implications of gal3 signaling on …
disorder for which no disease-modifying treatment exists. Neuroinflammation is central to the
pathology progression, with evidence suggesting that microglia-released galectin-3 (gal3)
plays a pivotal role by amplifying neuroinflammation in AD. However, the possible
involvement of gal3 in the disruption of neuronal network oscillations typical of AD remains
unknown. Methods Here, we investigated the functional implications of gal3 signaling on …
TARGETING GALECTIN-3 TO COUNTERACT SPIKE-PHASE UNCOUPLING OF FAST-SPIKING INTERNEURONS TO GAMMA OSCILLATIONS IN ALZHEIMER'S …
Y Andrade-Talavera, L Arroyo-García… - IBRO Neuroscience …, 2023 - ibroneuroreports.org
Alzheimer's disease (AD) is a progressive multifaceted neurodegenerative disorder without
disease-modifying treatment. Neuroinflammation is central to the pathology progression,
with evidence suggesting that microglia-released galectin-3 (gal3) plays a pivotal role by
amplifying neuroinflammation in AD. However, the possible involvement of gal3 in the
disruption of neuronal network oscillations typical of AD remains unknown. Here, we
investigated the functional implications of gal3 signaling on experimentally induced gamma …
disease-modifying treatment. Neuroinflammation is central to the pathology progression,
with evidence suggesting that microglia-released galectin-3 (gal3) plays a pivotal role by
amplifying neuroinflammation in AD. However, the possible involvement of gal3 in the
disruption of neuronal network oscillations typical of AD remains unknown. Here, we
investigated the functional implications of gal3 signaling on experimentally induced gamma …
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