Targeting heat shock protein 90 for the treatment of malignant pheochromocytoma
A Giubellino, C Sourbier, MJ Lee, B Scroggins… - PLoS …, 2013 - journals.plos.org
Metastatic pheochromocytoma represents one of the major clinical challenges in the field of
neuroendocrine oncology. Recent molecular characterization of pheochromocytoma
suggests new treatment options with targeted therapies. In this study we investigated the 90
kDa heat shock protein (Hsp90) as a potential therapeutic target for advanced
pheochromocytoma. Both the first generation, natural product Hsp90 inhibitor 17-allylamino-
17-demethoxygeldanamycin (17-AAG, tanespimycin), and the second-generation synthetic …
neuroendocrine oncology. Recent molecular characterization of pheochromocytoma
suggests new treatment options with targeted therapies. In this study we investigated the 90
kDa heat shock protein (Hsp90) as a potential therapeutic target for advanced
pheochromocytoma. Both the first generation, natural product Hsp90 inhibitor 17-allylamino-
17-demethoxygeldanamycin (17-AAG, tanespimycin), and the second-generation synthetic …
[PDF][PDF] Targeting Heat Shock Protein 90 for the Treatment of Malignant
A Giubellino, C Sourbier, MJ Lee, B Scroggins… - 2013 - academia.edu
Metastatic pheochromocytoma represents one of the major clinical challenges in the field of
neuroendocrine oncology. Recent molecular characterization of pheochromocytoma
suggests new treatment options with targeted therapies. In this study we investigated the 90
kDa heat shock protein (Hsp90) as a potential therapeutic target for advanced
pheochromocytoma. Both the first generation, natural product Hsp90 inhibitor 17-allylamino-
17-demethoxygeldanamycin (17-AAG, tanespimycin), and the second-generation synthetic …
neuroendocrine oncology. Recent molecular characterization of pheochromocytoma
suggests new treatment options with targeted therapies. In this study we investigated the 90
kDa heat shock protein (Hsp90) as a potential therapeutic target for advanced
pheochromocytoma. Both the first generation, natural product Hsp90 inhibitor 17-allylamino-
17-demethoxygeldanamycin (17-AAG, tanespimycin), and the second-generation synthetic …
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