… The second paragraph in the section titled "Challenges in targeting long non-coding RNAs"
on page 442 of this Review was inserted during manuscript revision. The wording of this …

… status of genomic loci and suppress the expression of target genes. This review will present
… to target lncRNAs for achieving therapeutic gene upregulation by de-repressing genes that …

… , the importance of long non-coding RNAs (lncRNAs) is … action at a therapeutically
efficacious concentration and, in … significantly suppress the target gene expression in a dose-…

… Long non-coding RNAs (lncRNAs) play key roles in human … HOTAIR target gene expression,
we measured levels of genes … a 3-fold increase in HOTAIR expression in ALDH1A1 positive …

… Targeting long non-coding RNAs therapeutically in cancer and … This enhances their target
gene expression and, in turn, … Targeting lncRNAs might be an alternative to upregulate …

… Amongst the most promising targets are long non-coding RNAs (… the safety of targeting
these lncRNAs therapeutically. There … gene expression networks through lncRNA targeting. …

… formed by non-coding RNAs offer alternative targets and … -coding loci, trans-acting long
non-coding RNA (lncRNA), pRNAs and … being used to upregulate gene expression address both …

… long non-coding RNA (lncRNA) that represent non-coding … long-term repression or activation
of target gene expression. The … A therapeutically relevant example of epimutation is caused …

… The role of non-coding RNA in treating various cancers is … siRNA therapeutics selectively
target gene expression in vivo, … at the same time can be therapeutically viable options in the …

… effort to therapeutically target these noncoding RNAs. In just … to balance X chromosome
gene expression by recruiting … PNAs can be conjugated to cholesterol moieties to increase …