5 天前 - … /MEK/ERK (MAPK) and PI3K-Akt-mTOR pathways due to mutations in genes …
targeting specific proteins within the RAS upstream and downstream signaling pathways in cancer…

44 天前 - … in activating downstream signaling pathways, including MAPK and STAT, and …
therapy has been observed, exhibited EGFR amplification and markers of activated RAS pathway…

45 天前 - … pathways. The findings of this review paper can potentially guide the development
of targeted therapies … IL-6/JAK/STAT3, Ras/Raf, AKT, MAPK, and NF-κB pathways. They also …

56 天前 - … to be stronger activated in the MSS patients whereas JAK-STAT and MAPK molecular
… novel targets. Assessing the immunogenicity of CRC tumors in the context of RAS/RAF …

57 天前 - … targeting the RAS/MAPK pathway have … targets that may mediate bypass of
therapeutic response to adagrasib/MRTX0902 or resistance associated with combination treatment …

71 天前 - … cancer is the leading cause of all cancer-related mortality worldwide. The RAS-RAF-MEK-ERK
(RAS-MAPK) signaling pathway … Somatic mutations in the RAS or RAF genes are …

85 天前 - … of cancer treatment. The … of the MAPK signaling pathway (ie RAF/MEK/ERK), and
it is for this reason that patients with KRAS mutant tumors are excluded from targeted therapies …

85 天前 - … of resistance to both conventional and immune therapies. As such, targeting
RAS/MAPK signaling is an attractive strategy. However, RAS/MAPK inhibition has not yet shown …

85 天前 - … with targeted therapy. Multiple tumor models with RAS/RAF/MAPK pathway activation
… -295 as a single agent or in combination with either chemotherapy or targeted therapy. …

85 天前 - … of MAPK signaling and activation of PI3K/AKT signaling play a major role in the
development of targeted therapy … tumor cells regulate these signaling pathways may yield new …