[HTML][HTML] Targeting virulence: salmochelin modification tunes the antibacterial activity spectrum of β-lactams for pathogen-selective killing of Escherichia coli
P Chairatana, T Zheng, EM Nolan - Chemical science, 2015 - pubs.rsc.org
New antibiotics are required to treat bacterial infections and counteract the emergence of
antibiotic resistance. Pathogen-specific antibiotics have several advantages over broad-
spectrum drugs, which include minimal perturbation to the commensal microbiota. We
present a strategy for targeting antibiotics to bacterial pathogens that utilises the salmochelin-
mediated iron uptake machinery of Gram-negative Escherichia coli. Salmochelins are C-
glucosylated derivatives of the siderophore enterobactin. The biosynthesis and utilisation of …
antibiotic resistance. Pathogen-specific antibiotics have several advantages over broad-
spectrum drugs, which include minimal perturbation to the commensal microbiota. We
present a strategy for targeting antibiotics to bacterial pathogens that utilises the salmochelin-
mediated iron uptake machinery of Gram-negative Escherichia coli. Salmochelins are C-
glucosylated derivatives of the siderophore enterobactin. The biosynthesis and utilisation of …
[PDF][PDF] Targeting virulence: salmochelin modification tunes the antibacterial activity spectrum of b-lactams for pathogen-selective killing of Escherichia coli
P Chairatana, T Zheng, EM Nolan - pdfs.semanticscholar.org
Bacterial infections, the rise in antibacterial resistance in hospital and community settings,
and the paucity of new antibiotics in the current drug pipeline create a worldwide public
health crisis. 1, 2 New strategies to diagnose and treat bacterial infections as well as
counteract the emergence and spread of antibiotic resistance in bacterial pathogens are
urgently needed to reduce morbidity and mortality, as well as the economic burden, caused
by these infections. 3, 4 The discovery of narrowspectrum antibiotics that target select …
and the paucity of new antibiotics in the current drug pipeline create a worldwide public
health crisis. 1, 2 New strategies to diagnose and treat bacterial infections as well as
counteract the emergence and spread of antibiotic resistance in bacterial pathogens are
urgently needed to reduce morbidity and mortality, as well as the economic burden, caused
by these infections. 3, 4 The discovery of narrowspectrum antibiotics that target select …
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