Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice
Abstract Aims Hutchinson-Gilford progeria syndrome (HGPS) is an accelerated ageing
syndrome associated with premature vascular disease and death due to heart attack and
stroke. In HGPS a mutation in lamin A (progerin) alters nuclear morphology and gene
expression. Current therapy increases the lifespan of these children only modestly. Thus,
greater understanding of the underlying mechanisms of HGPS is required to improve
therapy. Endothelial cells (ECs) differentiated from induced pluripotent stem cells (iPSCs) …
syndrome associated with premature vascular disease and death due to heart attack and
stroke. In HGPS a mutation in lamin A (progerin) alters nuclear morphology and gene
expression. Current therapy increases the lifespan of these children only modestly. Thus,
greater understanding of the underlying mechanisms of HGPS is required to improve
therapy. Endothelial cells (ECs) differentiated from induced pluripotent stem cells (iPSCs) …
[DOC][DOC] Telomerase Therapy Reverses Vascular Senescence and Extends Lifespan in Progeria Mice
Background: Hutchinson-Gilford Progeria Syndrome (HGPS) is an accelerated aging
syndrome associated with premature vascular disease and death due to heart attack and
stroke. In HGPS a mutation in lamin A (progerin), alters nuclear morphology and gene
expression. Current therapy increases the lifespan of these children only modestly. Thus,
greater understanding of the underlying mechanisms of HGPS is required to improve
therapy. Endothelial cells (ECs) differentiated from induced pluripotent stem cells (iPSCs) …
syndrome associated with premature vascular disease and death due to heart attack and
stroke. In HGPS a mutation in lamin A (progerin), alters nuclear morphology and gene
expression. Current therapy increases the lifespan of these children only modestly. Thus,
greater understanding of the underlying mechanisms of HGPS is required to improve
therapy. Endothelial cells (ECs) differentiated from induced pluripotent stem cells (iPSCs) …
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